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If you have questions or are interested in learning more about GeneFolio, submit this form or call 605-322-3050.

GeneFolio Pharmacogenomics

Our bodies process medications differently because of our unique genetic makeup. Sometimes what works for the average person may not work for you. For example, there are many medication options when it comes to treating depression and anxiety. That’s where GeneFolio® comes in.1

Genefolio logoUsing pharmacogenomics, GeneFolio Medication Analysis analyzes your DNA to provide insight into how your body processes medications, so you may be able to lower your risk of unwanted side effects and, with your provider, select a medication that is optimal for you.

Inspired Medicine by Avera

With a simple blood draw or saliva sample, GeneFolio Medication Analysis gives your provider access to testing that may help provide:

  • Optimal dosing based on metabolism
  • Increased chances for treatment success
  • Reduced potential for negative side effects

With GeneFolio, your treatment is guided by your distinctive genetic characteristics. This level of personalized care allows you and your doctor to see how medications are metabolized in your body to create a plan that’s right for you.

GeneFolio FAQ

How does GeneFolio Medication Analysis work?

Ask your physician or medical provider if GeneFolio testing is right for you. If so:

  1. Your Avera provider orders the test and takes a blood sample in the clinic.
  2. Avera’s genetic scientists at Avera Genetics analyze the sample, and the pharmacists generate a personalized results report for your doctor or provider.
  3. Your easy-to-understand report will tell you how your DNA may affect your body’s response to medications. The report is color-coded like a stoplight and identifies medications as green, yellow or red. Medications that are “green” may work well (the standard considerations apply). Medications in “yellow” might have a caution attached. Medications in “red” should be used with caution and may require more monitoring from your physician.
  4. You may schedule a follow-up appointment to discuss any potential medication changes.
  5. The report is saved in your Avera electronic medical record for future use, and you can view it in AveraChart under Reports.

Is GeneFolio right for me?

The best way to know if GeneFolio Medication Analysis is right for you is to talk with your Avera provider. However, nearly everyone may benefit at some point in their lives from receiving GeneFolio testing. Consider it especially if you:

  • Are preparing for upcoming surgery
  • Are being treated for behavioral health issues such as depression
  • Are being treated for cardiovascular disease
  • Need better pain control for chronic pain
  • Have experienced muscle aches and trouble taking a statin for cholesterol management
  • Take five or more medications

How do I order the GeneFolio test?

You need an appointment with an Avera provider to order the GeneFolio Medication Analysis test.

If you live in the Avera service area (South Dakota, Minnesota, Iowa, Nebraska and North Dakota), schedule an appointment with an Avera provider and ask about the GeneFolio test. Your Avera provider can order the test using the lab 605-322-3050. Find an Avera provider.

If you have a non-Avera provider and live outside the Avera service area, we recommend you visit with your physician or medical provider about your desire for pharmacogenomics. If you need further assistance, call 605-322-3050 or complete the contact form.

How much does the GeneFolio test cost? Is it covered by insurance?

GeneFolio is available starting at $179, plus lab fees. Insurance may cover the test in certain cases. Generally, Flexible Spending Account (FSA) and Health Savings Account (HSA) dollars can be used for the GeneFolio test. Check with your FSA or HSA administrator.

In the realm of health care tests, the cost of $179 is relatively low, especially considering the benefits. Plus, when you have co-pays and/or deductibles for prescription drugs, using pharmacogenomics, in addition to other clinical factors, may save you money and time.

How many genes are tested with GeneFolio?

GeneFolio Medication Analysis tests 15 genes that impact medications in four main classes: pain, depression and other psychotropic disorders, statins for cholesterol and certain types of blood thinners. Additional genes and medication classes will be added in the future.

How many medications are included in the GeneFolio test?

GeneFolio analyzes more than 150 medications with additional medications to be added in the future as the science develops.

How long are the results viable?

Your results are viable for a lifetime because DNA doesn’t change. For example, a patient who is tested now for pain management could use the results later when needing medication to control high cholesterol, and so on. Results are kept in your electronic medical record, which can be accessed by medical professionals at any Avera location.

1 GeneFolio may not be available in all states.